Dipartimento di Ingegneria Elettrica

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Molecular Devices Targeting Nucleic Acids

DNA repetitive sequences can form non-canonical supramolecular structures which can be exploited for targeting selected genomic regions. The probes used for reversible or covalent targeting and detection by emission have to be engineered by modern organic synthesis.

Obiettivi

Our research project is aimed at developing novel nucleic acid reversible and covalent binders susceptible of biocompatible activation, with recognizing properties toward guanine quadruplexes (G-quadruplexes, G4). Such an interest is driven by the suggestion that the selective targeting of G-4 represent the "chemical way" to control gene expression and to induce site-directed mutations, which might eventually lead to novel therapeutic agents for the treatment of cancer, and diagnostic applications.

Contenuti

Synthesis, Reactivity and Spectroscopic properties of water soluble and fluorescent Naphthalene Diimides, substituted Anthraquinones and Oligo-Heteroaryles

Campi di ricerca

Organic Chemistry, Photochemistry, Molecular recognition, Sensors, Selective ligand and probes for Nucleic acids, G-quadruplex structures, β-Lactam antibiotics

Metodologia

Organic Synthesis, Isolation, purification, structural characterization and reactivity of small organic ligands

Sezioni coinvolte

Organic Chemistry

Gruppo di lavoro

Prof. Mauro Freccero, Dr Filippo Doria (Third year Post-doctorate), Claudia Percivalle (Third year PhD student), Michele Petenzi (Second year PhD student), Luca Germani (Second year PhD student)

Collaborazioni

  • Dr. Marie-Paule Teulade-Fichou. UMR176 CNRS, Institut Curie, Centre de Recherche. Centre Universitaire, 91405 Orsay (France)
  • Dr Sylvain Ladame. Dep. of Bioengineering, Imperial College, London (UK)
  • Dr. Sara N. Richter, Dip. di Medicina Molecolare, Università di Padova
  • Prof. Claudia Sissi, Dip. di Scienze Farmaceutiche, Università di Padova
  • Dr. Nadia Zaffaroni, Dipartimento di Oncologia Sperimentale e Medicina Molecolare, IRCCS Istituto Nazionale dei Tumori, Milano
  • Prof. Stefano Alcaro, Dip. di Scienze della Salute, Università degli Studi “Magna Græcia” , Catanzaro
  • ACS Dobfar SpA